Beyond Rg BioSAXS
Next course is scheduled as satellite course for ACA meeting, July 14-17, 2025.
Solution small-angle x-ray scattering has earned great popularity and success in biological studies owing to the advances in brilliant x-ray sources, large area detectors, and, more importantly, data analysis methods in the past two decades. The objective of the “Beyond Rg: BioSAXS Short Course" is to raise the awareness and capabilities of the small-angle scattering (SAS) techniques in the structural biology community by providing an intermediate-level course for those in need of a better understanding of bioSAS theory, and techniques and facilities provided at the APS.
This bioSAXS short course will offer an overview of small-angle scattering (SAS, including x-ray and neutron scattering) theory, SAS methods and capabilities for structural biology, and data reduction and analysis tools, to enable the community to submit highly effective beam-time proposals and to facilitate better utilization of the resources at the APS. Although many methods covered in this course were originally developed for biomolecules which are often mono-dispersed, this course may be also useful for those work with solution samples with high structural homogeneity. However, this course is NOT for soft materials that are polydispersed.
Participants are expected to have attained at least a graduate student-level education and are encouraged to have a defined experimental program. Participants must bring their own notebook computers for software practice.
All participants should abide by the ACA Code of Conduct throughout the course. All participants can receive a complimentary ACA membership for the remainder of the year.
SYLLABUS
Fundamentals of Small-Angle Scattering
Small Angle Scattering Instrumentation
Fundamentals and Theories BioSAXS
Theories and Applications of BioSANS
BioSAXS Sample Preparation
Time-Resolved X-ray Scattering
Overview of ATSAS software package
ATSAS Software Practice
BioXTAS RAW Intro and Practice
Applying Beamtime at APS
SPEAKERS
Jesse Hopkins, BioCAT/IIT
Jan Ilavsky, XSD/Argonne
Irina Kosheleva, BioCAR/UChicago
Shuo Qian, ORNL
Soenke Seifert, XSD/Argonne
Max Watkins, BioCAT/IIT
Steven Weigand, DND-CAT/Northwestern
Xiaobing Zuo, XSD/Argonne
and other APS XSD and APS CAT's staff members
Last Webpage update 2/28/2025